منابع مشابه
Planning and analysis of cross-over trials in infertility.
The use of cross-over trials in investigating treatments for infertility is discussed. A simple possible approach to analyzing such trials using the Mantel-Haenszel procedure is explained. A more flexible approach based on the normal-binomial mixture model of Ezzet and Whitehead is examined. It is shown how this may be implemented in various statistical packages by applying it to two real examp...
متن کاملPractical Issues in Planning Cross-over Trials in Drug Development
Some practical issues in planning cross-over trials will be considered. A general approach to sample size determination for any arbitrary cross-over will be described. This also permits sample size determination when it is intended to recover inter-block information for incomplete block cross-overs. Consideration will also be given to planning to mimimize the effect of carry-over. Some aspects ...
متن کاملMeta-analyses involving cross-over trials: methodological issues.
BACKGROUND Meta-analysis of randomized controlled trials (RCTs) is usually based on trials where patients are randomized individually into two different, parallel, treatment groups. This paper concentrates on RCTs of a different design-two-period, two-treatment cross-over trials. METHODS The characteristics of these trials are outlined, with detailed examples of methods for analysis for both ...
متن کاملEditorial Biomarkers in Clinical Trials
In contemporary cardiovascular practice, the most common and useful applications of biomarkers focus on disease diagnosis, with troponins for myocardial infarction and natriuretic peptides for heart failure representing the most notable examples. Identification of additional cardiovascular diagnostic markers has proved challenging, however, because high quality studies for diagnostic indication...
متن کاملValidity and cross-validity in HCI publication
Papers in HCI play different roles, whether to inspire, solve industrial problems or further the science of HCI. There is a potential conflict between the different views, and a danger that different forms of validity are assumed by author and reader — deliberately or accidentally. This paper reviews some of the issues in this complex area and makes practical recommendations. In particular, the...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1979
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1979.tb05902.x